Synthesis, Characterization and Cytotoxicity Activity Study of Some pyrazoline Derivatives from chalcone Derived from 2- (1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene) malonaldehyde

Abstract

This research involved the synthesis of a number of novel pyrzolines derived from indol compounds. The condensation reaction of the chalcon derivatives (D1-D4) with hydrazine hydrateproduce pyrzoline derivatives (D5-D8). Spectroscopic methods were used to confirm and describe the structure of compounds (FT-IR, 1H-NMR). The cytotoxic activity of target substances at various doses against the human breast cancer cell line MCF7 was examined. The findings indicated that the substances had potential cytotoxic activity against the MCF7 cell line, particularly substance (D7), which had the strongest inhibition at a rate of 100 µg/ml among the substances tested at various concentrations.