Evaluation of LRRC17 and Periosten for Osteoporosis Patients

Abstract

Osteoporosis is a metabolic bone disease that results, at the cellular level, in osteoporotic bone resorption that is irreplaceable by osteogenesis of osteoblasts. This leads to weak bones and causes osteoporosis, which leads to an increased risk of fractures. Aim of Study: the current study aimed to detected biomarkers in patients with osteoporosis and it association with some physiological status have been a study because increase incidence of osteoporosis, for both genders which might also help in early diagnosis of case of osteoporosis to prevent development of complication, this achieved by: Estimation of some biomarkers include Leucine-rich repeat-containing 17 and Periostin .Result , The study, higher serum periostin levels have been reported to be associated with increased fracture risk in postmenopausal women The perostin parameter in the current study was highly significant increase in osteoporosis age group (41-50 y) patients (27.81±5.86) than in control age group (41-50 y) (14.91±0.52) according to p-value (0.002) , demonstrated that postmenopausal women in the lowest plasma lrrc17 tertile had higher, The LRRC17 parameter in the current study was highly significant increase in osteoporosis age group (41-50 y) patients (712.33±60.68) than in control age group (41-50 y) (311.22±21.64) according to p-value (0.001).