Study of the Biological Activity of Some new Heterocyclic Compounds Prepared from Benzoimidazole Derivatives

Abstract

This study synthesised and characterised new five- and seven-member heterocyclic compounds (imidazolidine, Thiazolidine and oxazepine). The first step in clude react o-phenylene diamine with salicylic acid to get Benz imidazolidine derivative (1). and the second step react p-amino acetophenone with Sodium nitrite to get diazonium salts after this add the mixture to derived (1) to get Azo dye derivative (2) the three steps react (2) with 2_amino pyridine to get schiff base (3) derivative. (3) wit with (alanine, glycine, thioglycolic acid, phthalic anhydride, maleic anhydride) to get imidazolidine (4,5), Thiazolidine (6), oxazepine(7,8) derivatives. These compounds' properties; their composition. Staphylococcus aureus (Gram-positive) and Escherichia coli (13C-NMR) were used for identification, ('H NMR), (13C-NMR) and (FT-IR), and their biological effects were studied (Gram Negative).