Role of Supar and Some Other Biochemical Parameters in Diabetic Nephropathy

Abstract

Diabetes mellitus (DM) is a disorder that occurs due to metabolic problems and is most frequent globally. Diabetic nephropathy is a common complication of diabetes and the leading cause of chronic kidney disease. Soluble urokinase plasminogen activator receptor (suPAR) is the circulating form of a glycosyl-phosphatidylinositol-anchored three-domain membrane. Protein Urokinase-type plasminogen activator is a trypsin-like serine protease that plays a vital role in the extracellular conversion of inactive plasminogen into catalytically active plasmin. Methods: Blood samples were taken from 90 patients and 30 healthy people, the suPAR levels were determined by using Elisa kits, while protein urine was by urine dipstick. Result: the levels of suPAR in the studied groups there was a highly significant increase of (p˂0.001) in the three patients’ groups compared with a control group. Also, there was a highly significant increase of (p˂0.001) in the diabetic nephropathy and nephropathy groups compared with the diabetes mellitus group and a highly significant increase of (p<0.001) in the diabetic nephropathy group compared with the nephropathy group. The criteria diagnosis validity of suPAR level in groups: The optimal cut-off value for suPAR in all groups of patients compared with control estimated from ROC curves, according to these results, the test is positive if test ≤ threshold value (criterion values) for diabetes group, while > threshold value for nephropathy and diabetes nephropathy groups.  These results indicated that: the variable is closely related to diabetic nephropathy more than it is to diabetes.