Evaluation of Histological Changes Resulting from Effect of Antimony on Structure of the Testes in the White Rabbit Orectolagus Cuniculus

Abstract

The current study was conducted to investigate the effect of antimony in the testes of male adult white rabbits, Orectolagus cuniculus, treated with two concentrations 20 and 30 mg/kg/day for a period of 30 days. 18 rabbits were used, divided into three groups, each group included 6 rabbits. The first group (the control group) was dosed with distilled water. The second group (the first experiment group) was dosed with antimony at a concentration 20 mg/kg/day, and the third group (the second experiment group) was dosed with antimony at a concentration 30 mg/kg/day, and the tissue sections were prepared using the paraffin method. The results of histopathological changes of the testis tissue showed the occurrence of dissociation in the germ cells. And the separation of the epithelial layer from the basement membrane and a contraction in the walls of some semiferous tubules, where their general appearance became wavy and irregular Irregularity of the epithelial layer of some seminiferous tubules, The results of the study showed an increase in the thickness of the wall of some seminiferous tubules. In addition, it was observed and the appearance of vacuolation between germ cells in some seminiferous tubes. Degeneration is degeneration in Sertoli cells. It was also observed that some germ layer cells sloughed off and gathered in the lumen of the seminiferous tubules, Pyknosis of some germ cells and Karyolysis of some germ cells, where the nuclei completely disappeared, and Hydropic Degeneration was also seen in some germ cells.