ACE2 Gene Polymorphism Association COVID-19 Patient

Abstract

Background: Many SNPs in ACE2 gene polymorphism have been identified and linked COVID-19 in human. Objective: Study the prevalence of rs4646116, rs2285666, rs143936283 gene polymorphism in an Iraqi population. Materials and methods: Amplification-refractory-mutation -system (ARMS-PCR) technique was used to identify rs4646116, rs2285666, rs143936283genotypes in all 86 patients. Results: The genotypes of the targeted SNP were distributed as following: (rs4646116: CC (17.3%), C/T (34.6%)), TT (48.1%), (rs2285666: AA (15.4%), A/G (25.0%), GG (59.6%)), (rs143936283: CC (25.0%), C/T (26.9%) TT (48.1%)). Conclusion: ACE2 single nucleotide polymorphism of rs4646116, rs2285666 and rs143936283 showed no significant variation between co-infection and cases of pure COVID-19 infection however, several genotypes were more frequent than others and can play a risk role in susceptibility to COVID-19. And these SNPs had no correlation with severity of disease