The Effect of Vitamin D Level on Some Biomarkers of Inflammation and Oxidative Stress in Atherosclerotic Patients

Abstract

Atherosclerosis is a chronic disease around the world and is the main cause of death risk for patients with atherosclerosis and type 2 diabetes. The study aimed to evaluate the effect of vitamin D on a number of non-traditional biomarkers overlapping in the processes of inflammation and oxidation in patients with atherosclerosis. The study was conducted on patients referred to specialized clinics in Kirkuk and Cardiology Hospital in Sulaymaniyah for the period from August 2021 to January 2022 and included sixty samples of men whose ages ranged between 40 and 70 years, distributed into three groups, the first included twenty men with atherosclerosis, the second group included twenty men with atherosclerosis and type II diabetes, and the third group included twenty healthy men within the same age range. The results showed a significant decrease in the groups of atherosclerosis and atherosclerosis with diabetes compared to the control group for the level of vitamin D, and there was a significant increase in the levels of PTX3, Interlukin 10, OxLDL and hsCRP in the groups of atherosclerosis and atherosclerosis with diabetes compared to the control group. It is concluded that vitamin D deficiency may be associated with increased production of reactive oxygen species, poor antioxidant capacity, and low anti-inflammatory properties that are extremely important in the development of atherosclerosis event.