Synthesis, Spectral Characterization and Biological Activity of new niii, Coii and Cuii Complexes with Thiosemicarbazide Ligand

Abstract

The research included the preparation and characterization of the new thiosemicarbazide ligand; N1-(dimethylcarbamoyl)-lhydrazine-1,2-bis (carbo-thiomide) (L). Three transition metal complexes were isolated from the mixing of the title ligand with the metal ions of (Ni(II), Co(II) and Cu(II)). The reaction was performed by mixing metal:ligand in a 1:1 mole ratio using EtOH as the medium. The chemical formula of L complexes is presented as follows; [LNiCl2H2O], [LCoCl2H2O] and [LCuCl2H2O], The entity of the expected structure of the ligand and its metal complexes were illustrated through a range of physicochemical techniques. These include; FT-IR electronic spectra, 1H- and 13 C- NMR spectra, elemental analysis (CHNS), chloride content, metal content, melting point, molar conductivity and magnetic susceptibility measurements. The spectral and analytical analyses concluded the isolation of six-coordinate complexes for the (Ni(II), Co(II) and Cu(II) with a distorted octahedral geometry about the centre atom. The anti-bacterial activity (G+ and G- bacterial) was explored.