Assessment of Presepsin and Calprotectin in Critically ill adult Patients with Sepsis

Abstract

the goal of the study is to evaluate the diagnostic utility of Presepsin& Calprotectin as biomarkers compared to the traditional used diagnostic methods in addition to investigate bacterial pathogens causes of septic patients. Method: A total of forty blood samples were obtained from clinically diagnosed adult sepsis patients (sepsis group). The samples were collected from both sexes (20 males and 20 females ranging in age from (17 to 72) years’ old who were at the ICU at Al-Hussein teaching hospital in Karbala and the Obstetrics hospital in Karbala city/Iraq between (November 2021 and April 2022). Result: calprotectin and presepsin levels in patient group were elevated compared to control group which is significant for calprotectin (P=0.019) but did not reach statistical significance for presepsin. clarified association between Calprotectin & Presepsin serum levels and sofa score in patient's groups, which revealed that calprotectin serum levels mean were (67.99±47.9, 69.23±41.1, 77.69±55.6) from the lowest to highest score (no significant, P =0.929). Whereas mean Presepsin levels were (312.8±448.8, 153.3±89.9, 220.02±125.7) respectively and again non statically significance is obtaine(P=0.452). Conclusions: calprotectin and presepsin levels elevated in adult sepsis, calprotectin & presepsin could be regarded as good biomarkers for diagnosis of sepsis. In addition, both study markers have relevant specificity for diagnosis of sepsis. No association between severity of sepsis and levels of study markers