Study of Histopathological Changes of Ag Nps in Quail Kidney

Abstract

Nanotechnology is one of the most promising technologies of the twenty-first century, as silver nanoparticles have access to enter the body due to their small size, which are the skin, respiratory and digestive systems. This study was conducted to investigate the histological changes caused by silver nanoparticles on the kidney of Japanese quail. 100 birds were obtained from the College of Agriculture and division into five groups, where each group included 20 birds. The first and second groups were treated with a chronic treatment, which was dosed with silver nanoparticles for 30 days, as for the third and fourth groups, they were treated with the acute treatment and dosed for 3 days only with the AgNPs, as well as the control group, which was dosed for 30 days with distilled water. The results of the chronic treatment after 10 days of dosing showed Hemorrhage and degeneration of epithelial cells Renal tubules, while the acute treatment showed intercellular hemorrhage and degeneration and glomerular shrinkage, the results were more severe after 30 days of treatment, which showed swelling of the epithelial cells, hemorrhage between the tubules and inside the glomerulus, and obstruction of the renal tubules. We conclude from this study that taking AgNPs orally caused histopathological changes to the kidney, which were represented by hemorrhage between the tubules and inside the glomerulus, as well as degeneration of epithelial cells and shrinkage of the glomerulus, in addition to swelling of the epithelial cells with the presence of infiltrating cells between the tubules, and this explains that silver nanoparticles have toxic effects on the quail kidney.