The Influence of Some Vitamins and Biochemical Parameters on Iraqi Females’ Patients with Malignant Breast Cancer
Keywords:
Breast Cancer (BC), Vitamin D (Vit D), Body Mass Index (BMI).Abstract
Background: Cancer is one of the most common and deadly diseases in humans, and breast cancer (BC) is the second type of cancer among women, and it is the second cause of death, while lung cancer is the first, in agreement with the World Health Organization (WHO). Objective: To find the effect some vitamins and their relationship on the development of malignant breast cancer for Iraqi women. Methods: For purpose of starting the study, we decided to take (80) women as a sample of this study and they were split into two categories, the 1st category include (40) females as patients related breast cancer who taking vitamins pills as treatment, and the second group include (40) women as healthy subjects. Both groups had tests such as vitamins D, E and A, malondialdehyd (MDA), liver function Aspartate Aminotransferase (AST/ GOT) and Alanine transaminase (ALT/ GPT). Body mass index (BMI) and estradiol hormone (E2) concentration were measured as well. The patients were given vitamin D as (D3) pills (5000/ IU), vitamin E pills (400/IU), and vitamin A pills (10000/IU) one pill per day for a month. All vitamins as well as MDA were measured after taking medication for a month. Results: After laboratory measurements, the results were statistically analyzed. There was a strongly noticeable where (P<0.001) variation in vitamin D when comparing patient group with control. Vit E, A, MDA, BMI. When comparing the estradiol hormone of the healthy group with the group of patients, there was a statistically significant relationship (P≤0.05). On the other hand, we did not notice any significant relationship with regard to liver enzymes for the same groups (P>0.05). Vitamins D, E and A as well as MDA concentrations were elevated after taking medication for a month. Conclusions: Maintaining the normal level of vitamins in addition to maintaining a normal body weight plays an important role in reducing the development of breast cancer.
