Evaluation the Polymorphism of IFITM3 Gene and its Role in Covid 19 Infection Outcome and Disease Severity in Babylon Province

Abstract

By preventing viral membrane hemifusion between the host and viral cell cytoplasm, the interferon-induced transmembrane protein 3 (IFITM3) contributes significantly to the adaptive and innate immune response. Incidence and severity of influenza or other viral infections have been linked to single nucleotide polymorphisms (SNPs) in the gene IFITM3. Our goal was to examine how SNPs in the gene IFITM3 affected SARS-CoV-2 infection. The study's sampling took place on Covid-19, a subject patient in Babylon Governorate, between October 24, 2021 and November 1, 2022.

There were Four single-nucleotide polymorphisms (SNPs) were genotyped in the 305 base-pair PCR results of the IFITM3 center advertiser locale around record start site (rs6598045), (rs7478728), (rs71452596), (rs7479267). Every one of these SNPs were in Hardy-Weinberg harmony (P.0.05) both in the Covid -19 and control gatherings. was found among three SNPs, rs7478728, rs71452596 and rs7479267.