Community-Acquired Pneumonia: Immune and Metabolic Disorders Before and After Treatment

Abstract

Community-acquired pneumonia is one of the most common infectious diseases in the world and in the Russian Federation, having kept on being the leader among infectious causes of death. We have studied immune and metabolic disorders before and after standard therapy in patients with community-acquired pneumonia. The patients included in the study had laboratory criteria revealed indicating the presence of immune inflammation, oxidative stress, endothelial dysfunction, and activation of lipid peroxidation. The provided standard treatment does not normalize most of the changed parameters of the immune and metabolic status, which necessitates the search for methods for correcting disorders by using various combinations of immunomodulatory and antioxidant drugs in combination pharmacotherapy.