Evaluation Role of Coenzyme Q10 in Patients with Ischemic Heart Disease

Abstract

Background: The Coenzyme Q10 has a potential role for prevention and treatment of cardiovascular diseases by improving cellular bioenergeticsAim of study: To evaluate the role of coenzyme Q10 and other biochemical parameters in ischemic heart disease (angina pectoris and myocardial infarction).Methods: A case control study conducted at Intensive Care Unit of Ibn-Sina Teaching Hospital and Al-Salam General Hospital in Nineveh Province, Iraq for the period of two months from 1st April to 1st June 2022. It included 90 adult participants divided into two groups: Case group included 60 patients admitted to the Intensive Care Unit and diagnosed with ischemic heart diseases (Myocardial infarction or angina pectoris) and control group included 30 healthy participants matched in age and gender with case group. Subsequent assay of lipid profile, CRP, CPK, troponin level, and serum coenzyme Q10Results: In this study, 81.7% of patients in case group were diagnosed as myocardial infarction. Means of S. LDH, CRP, CPK, and troponin were significantly higher; while means of coenzyme Q10, S. cholesterol and S. HDL were significantly lower in case group than that in controls. Statistically significant moderate negative correlation was detected between coenzyme Q10 level and age; while significant weak negative correlations were seen between coenzyme Q10 level and all of S. LDH, CRP, and troponin level. Conclusion: Patients with ischemic heart diseases had considerably low serum levels of coenzyme Q10 compared with control group. The highest mean of lipid profile except TG in patients with IHD compared with control group explain the role of cholesterol compounds in progression of IHD. No significant correlations between coenzyme Q10 with BMI, s. cholesterol, s. TG, s. HDL, and CPK. Negative correlation between coenzyme Q10 with age, s. LDH, CRP, and troponin