Determination a role of some immunological markers for diabetic patients in Diyala province

Abstract

Background;Diabetes Mellitus (DM) is a metabolic disease, involving inappropriately elevated blood glucose levels . DM has two categories, including type 1 and type 2 diabetes. Aim of study; the present study aimed to investigation the role of interleukins IL-15, IL-33, and IL-36 in pathogenesis of diabetes mellitus. Materials and methods; 90 blood samples were obtained from the consultative clinic - Baquba Teaching Hospital - Diyala Health Department, within period from beginning of October 2021 to end of January 2022. The samples were classified into groups as follows: 60 blood samples from DM patients , where the number of males was 28 and the number of females 32 within age range 21-70 years. Addionally, 30 samples of apparently healthy people of both sexes were adopted and used as a control group, where the number of males was 15 and the number of females 15 within the age range 21-70 years and they did not suffer from any chronic or acute illness at the time of sample collection. Results; Results our study revealed significant different among age groups, where the 41-50 and 51-60 years scored highest percentage (25.60% and 28.90%) than 21-30 and 31-40 that scored least percentage (11.10% and 15.60%). Additionally results of current study mentioned the decreased median levels of IL-15, IL-33, and IL-36 parameters in patients (145.97, 222.89 , and 306.72) than healthy (149.50 , 249.33 , and 548.94) respectively with significant different for IL-36 (p<0.05) and non-significant (p>0.05) for IL-15 and IL-33. Addionally, present study revealed no significant differences between interleukins and age, gender, and disorders. Finally, IL-33 scored highest sensitivity (41%) in screening diabetes. Conclusions; decreased levels of interleukins IL-15, IL-33, and IL-36 in patients with diabetes.