Assessment levels of Hepcidin in patients with Hepatitis B and C: A comparative study

Abstract

The study aimed to study the effect of Hepcidin levels by viral hepatitis B and C to indicate which is of them is more effect on liver functions. Researchers at Medical city in Baghdad, Iraq, will investigate the prevalence of parameter markers in patients with viral hepatitis B and hepatitis C. The study includes 47 patients with hepatitis (25 with hepatitis B and 22 with hepatitis C) and 19 healthy people as controls. Both patients and controls had blood drawn to estimate Hepcidin by ELISA and AST, ALT and alkaline phosphates by Fujifilm device according to manufactured company. The average hepcidin level in patients with hepatitis B was 1551.38 mg/dl and in hepatitis C patients was 1600.19 mg/dl compared with healthy as control 1547.86mg/dl indicating no significant difference between the two groups, Also for ALT in hepatitis B patients 31.71 mg/dl and in hepatitis C 28.29mg/dl compared to 36.07mg/dl in their healthy, indicate is no significant difference. Also, the level of AST (28.19mg/dl) in hepatitis B and 31.21mg/dl in hepatitis C compared with 31.38 in healthy persons indicate is no significant difference. For Alkaline phosphatase, the average level in hepatitis B was 191.83, in hepatitis C was 128.74 and in healthy was 136.82 there were significant differences at P value 0.01 between the pathological cases of viral hepatitis B, C. It was concluded For Alkaline phosphatase, there were significant differences at P value 0.01 between the pathological cases of viral hepatitis B, C. As for the links between the comparison, most of them were positive and non-significant except for the ALT with AST, it was a highly significant association. It was the opposite and non -significant connection between the alkaline phosphatase and the hepcidin.