Evaluation of FSH and inhibin B in male after covid 19

Abstract

Background: Coronavirus 2019 (COVID‐19) is a novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2, it affects all systems in human body even reproductive system. Aim of the study: The aim of this study was to evaluate hormonal dysfunction in male after Covid-19 recovery by estimation of luteinizing hormone, testosterone and inhibin-B. Material and Methods: A cross-sectional study was carried out in Salah Al-Din Governorate from of December 2021 to the end of April 2022, included 60 patient who have +ve PCR of previously hospitalized and with oxygen ventilation and have moderate to severe covid-19 after 6 months of recovery, the second group 30 patient that apparently be healthy as control group and evaluation of total testosterone, luteinizing hormone , Inhibin-B by enzyme linked immunosorbent assay technique. Results: The study showed no significant difference between Covid-19 patients (6 months after recovery) and health control group, the mean age of patients was 33.11 year. The study showed that the lowest mean of testosterone was recorded among Covid-19 patients (2.78 ng/ml) as compared with healthy control individuals (7.43 ng/ml) at P. value <0.001. The study showed that the mean of inhibin-B was highly reduced in recover Covid-19 patients (41.13 pg/ml) comparing with control group (76.84 pg/ml) at P. value <0.001. The study showed that the mean of luteinizing hormone was elevated significantly in recover Covid-19 patients (5.80 IU/L) comparing with control group (2.39 IU/L) at P. value <0.05. The study showed significant negative correlation between CRP and each of testosterone and inhibin-B among recovered Covid-19 patients and significant positive correlation with luteinizing hormone There was a significant negative correlation between luteinizing hormone and testosterone. Conclusions: There was a significant relation between male dysfunction and Covid-19 infection and low levels of inhibin-B and testosterone were recorded among recover Covid-19 patients comparing with healthy individuals.