Evaluation the Protective Effect of Capparis spinosa Fruits Hydroalcoholic Extract Against Hepatotoxicity Induced by Cisplatin in Rats

Abstract

The present study was carried out to evaluate the liver abnormality change, hepatotoxicity after using the cisplatine and investigate the protective effect of capparis spinosa fruit extract against these effects and evaluate the liver function (AST, ALT, ALP), serum lipid profile (HDL, LDL, VLDL, Triglyceride and cholesterol) and histopathological changes of liver. Twenty-one male rats were randomly divided into three groups (7rats/ each). First group was received distilled water orally for 10 days and served as negative control group. Second group was received cisplatin only (10 mg/kg, i.p.) as a single dose at day 8 and served as a cisplatin treated group. Third group was received capparis spinosa fruit extract (100 mg/kg B.W) for 10 days and 10 mg/kg cisplatin as a single dose at day 8. The results showed that the animals that treated with cisplatine alone were suffered from liver damage by significant increasing in the liver enzymes, induced histopathological changes, significant increasing in lipid profile (except HDL, which significantly decreased). While the third group (that treated with hydroalcoholic extract of capparis spiosa fruit showed significant decreasing in the liver enzymes as compared with second group and decreasing in the histopathplogical changes in the liver, while there were significant decreasing in lipid profile (except HDL, which significantly increased). Conclusion: In this study cisplatine induced histopathplogical changes, alteration in the liver function and produced increasing in the lipid profile, while the (hydroalcoholic extract of capparis spiosa fruit) was have ability to maintain liver function and induce the decreasing in the lipid profile.