Synthesis, characterization, and cytotoxicity of Zinc phosphate nanoparticles on the HL-60 human leukemia cell line

Abstract

Nanoparticles are successfully replacing anticancer medicines in medicine (NPs). In this study, the co-precipitation approach was used to create ZnP-NPs. ZnP-NPs particles in the XRD had an average size of 37.54 nm, whereas ZnP-NPs particles in the SEM had an average size of 78.56 nm. They were detected using various techniques, including FTIR, XRD, EDX, and SEM. According to EDX results, which showed that zinc (55.7%) and oxygen (24.7% of the sample) were present, the synthesized NPs have a high purity level. Furthermore, low Phosphorous concentrations (19.6%) suggest that the manufactured material is of sound purity. ZnP-NPs were evaluated on human cancer HL-60 cells at different concentrations (25, 50, 100, 200, and 400 µg/ml). After 24 hours, the killing rate was 6.5%, 15.2%, 23.8%, 38.2%, and 63.3%, in that sequence. Chemical precipitation is a better method for killing or inhibiting. Half-maximal inhibitory doses (IC50) for ZnP-NPs are 270.5 µg/ml. ZnP-NPs have potential therapeutic advantages as anticancer drugs. The drug was safe at all concentrations (not harmful).