An Association of High Mobility Group Box-1 with Lipid Profile in Iraqi Patients with Unstable Angina

Abstract

Background: Numerous studies have recently looked into the function of inflammation in coronary artery disease and the relationship between inflammatory biomarkers and unfavorable outcomes. This study is focus into the association between Lipid Profile of serum High mobility group box 1 (HMGB1) protein and known risk factors for Unstable Angina. Methods: The study involved 50 participants 20 female and 30 male and 40 controls 20 female and 20 male who came to Al Ramadi Teaching Hospital issues between November 2021 and April. The average age of patients was 52.16±8.423 years, compared to 49.58±8.098 years for controls. Results: In our investigation, we found that UA patients had much higher TG, LDL, and VLDL levels than controls, while controls had significantly lower levels of HDL. Total cholesterol, TG, LDL, and VLDL levels in patients with unstable angina were shown to be greater than in the control group.

Conclusions: The study found that blood levels of LDL, TG, and VLDL, which are risk factors for potential heart and blood vessel illnesses, are increasing in people with unstable angina. Patients with unstable angina had increased serum HMGB-1 levels, and all of these indicators can be utilized to identify these patients.