Correlation Between Cyp2r1 Gene Polymorphism and Vitamin D3 Deficiency in A Sample of Iraqi Population

Abstract

Lack of vitamin D can induce bone density loss, which can result in osteoporosis and fractures (bone fractures). Severe vitamin D deficiency might lead to other illnesses. might result in rickets. Rickets is a rare disease that causes brittle, fracture-prone bones. The CYP2R1 gene contains instructions for producing the 25-hydroxylase enzyme. In order to transform vitamin D into its active form, 1,25-dihydroxyvitamin D3, commonly known as calcitriol, this enzyme performs the first of two reactions. This study intends to examine the relationship between vitamin D3 deficiency and CYP2R1 gene polymorphism in a sample of the Iraqi population. There were 60 participants in this research with vitamin D3 insufficiency. The amplified products' sequencing results were obtained for this investigation and then aligned to the NCBI's blast database. The genetic susceptibility to Vitamin D3 Deficiency in Iraqi individuals may be influenced by CYP2R1 single nucleotide variation (SNPs).