The Association of Ketogenic Diet on Hormonal Regulation of Energy Metabolism; a thesis

Abstract

Objectives: The purpose of this study is to estimate the role of ketogenic diet on weight loss and improvement of glycemic index by regulating the blood glucose level, Insulin, and Insulin Resistance. And evaluating the role of keto diet on satiety hormone) Leptin,). Material And Methods: This is cohort study carried on in Salah al-Din Governorate in Balad city in the first of September 2021 till the end of December 2021 in group for keto diet 48 women and 11 men who followed the keto diet for 12 weeks. Their age between (18_60 year) and their weight were (65_132) kg, and BMI (26 _ 45) kg/m2. The study based on the measure the BMI, and measure the FBS, and measure the Hormones (Insulin, and Leptin) by ELISA for all subjects before and after the Keto Diet. Results: The mean of BMI significantly decreased after the keto diet range from (34.37 to 31.40) with T value = 3.09. The current study shows significant decreased in glycemic index, FBS mean range from (126.7 to109.7) with T value = 2.21. and HbA1c mean range from (5.93 to 5.46) with T value = 2.76. And the study shows non-significant difference in Hormonal-regulating energy (Insulin) mean range from (1.419 to 1.319) T value= 1.40, but the study shows significant decrease in Insulin Resistance mean range from (0.448 to 0.360) T value = 2.19. The current study shows strong positive correlation between Insulin and Insulin Resistance. And show non-significant decrease in satiety Hormones (Leptin) mean range from (1.274 to 1.126) with T value = 1.40. Conclusion: The present study shows the beneficial effects of Keto Diet. It significantly reduces the BMI and decreased level of blood glucose, and improve of Insulin Resistance, whereas non-significant differences in hormones level of Insulin, Leptin.