Determination Spectrophotometric and Cloud Point Extraction of Hydroxychloroquine Sulfate (HCQ) Drug
Abstract
Using Cloud Point Extraction (CPE) technology to separate, enrich and extract hydroxychloroquine sulfate (HCQ) in the form of an ionic bonding complex, and the complexing agent Anthra chiono sulfonsaure-2-Natriumsalz was used in this compound UV-VIS wavelength spectrum to confirm its structural formula on its greatest wave 411nm Optimum conditions for extraction and spectroscopic determination of HCQ were found: HCQ concentration and reagent (100 µg.ml-1) (1 10-3M) respectively, Triton-114 V/V (10%) . and heating (30min), centrifugal speed of 4000 r/min, the linear concentrations range that obeyed Beer's is (2-18 μg.ml-1) and value correlation coefficient R2 = 0.9978, limit of detection LOD (0.0461μg ∙ ml-1), limit of quantification LOQ (0.1397μg ∙ ml-1), and mole ratio were studied in order to optimize the reaction conditions. The mole ratio for the composition of product is (1:1). molar absorption coefficient (1386.44 l mol-1. cm), Sandel sensitivity (0.0197 µg.cm 2),
