Association of Helicobacter Pylori with Psoriasis in Kerbala Province, Iraq

Abstract

Background Chronic immune-mediated disease with both cutaneous and systemic manifestations is psoriasis. It had been documented the presence of a link between certain types of microorganisms and the onset of Psoriasis and its worsening. Aim of the study: The aim of the study was to investigate the association between Helicobacter pylori and psoriasis and the severity of the disease. Methods Thirty-one psoriatic patients and thirty-one age and sex match healthy control subjects were enrolled. Blood samples were collected. The patients were classified according to PSAI score to mild, moderate, and sever cases. the presence of H. pylori antibody was detected by using rapid test cassette Statistical Analysis IBM SPSS version 24 software was used for analysis. Data were expressed as the frequencies, Means, Standard deviation were used, P value (P≤ 0.05) was considered statistically significant. Results: The current study revealed that 51.6% of psoriatic patients were seropositive to H. pylori IgG. there were significant association between the presence of H. pylori IgG and PASI score of severity. Patients with severe psoriasis had an H. pylori IgG positivity rate of 70%, while those with moderate psoriasis had a 72.7 % positivity rate. H. pylori IgG positivity was only found in 10% of patients with mild psoriasis. Conclusion Approximately 52 % of patients had H. pylori IgG. Significant association between the presence of H. pylori IgG and PASI score of severity was observed, thus, H. pylori could be considered as risk factor for psoriasis.