The Prevalence of Toll-Like Receptor 3 (Rs13126816) Genotype: A Study on Iraqi Children

Abstract

Background: Many SNPs in TLR3 gene have been identified and linked to many diseases in human. Objective: Study the prevalence of TLR3 rs13126816 gene polymorphism in an Iraqi population. Materials and methods: Amplification-refractory-mutation -system (ARMS-PCR) technique was used to identify rs13126816 genotypes in all 93 healthy children. Results: The genotypes of the targeted SNP were distributed as following: AA (45.1%), A/G (34.4%), GG (20.5%). Conclusion: The most prevalent genotype of the TLR3 SNP was the wild genotype and the mutant allele represented about one third of total count of alleles