A Relationship of Caveolin-1 with Lipid Profile and a Number of Anthropometric Measurements in Iraqi Myocardial Infarction Patients

Abstract

Myocardial infarction (MI) represents the most common death and morbidity cause all over the world, as it is responsible for as many as 40% of all of the death cases. Atherosclerotic inflammation has a role in the formation of coronary plaque as well as its advancement to unstable state, which results in causing MI. In the present study, there is an attempt for measuring whether there are any associations of the Caveolin-1 (CAV-1) with lipid profile parameters and some anthropometric measurements (AMs) such as waist / hip (W /H), waist/ thoracic (W /T), and waist/ nick (W /N) in Iraqi MI patients. This study involved 42 MI patients from Al-Fallujah teaching hospitals, in addition to 42 healthy people who served as controls. ELISA was used for the purpose of determining the level of CAV-1 in the serum, while TG, T.Cho, HDL, CPK (MB), and cTn-T were determined by enzymatic colorimetric methods. Serum level of CAV-1 has been lower in MI patients when compared with it in the healthy people (P< 0.000l), but cTn-T and CPK (MB) compared to HCs, were considerably greater in MI patients. (P < 0.000l). CAV-1 has an important negative correlation with cTn-T, CPK (MB), LDL/HDL and TC/HDL (P< 0.000l), while it showed positive correlation with HDL (P < 0.000l). The studied parameters showed the descending order of the area under receiver operating characteristic (AUROC) curve: cTn-T was (1), CPK (MB) (1), CAV-1(0.913), HDL (0.999), T. Cho. /HDL (0.905), TG (0.891), VLDL (0.891) LDL (0.721), W/H (0.804), W/N (0.727), W/T (0.661). Serum CAV-1level can be used as a novel biomarker in the detection of MI and may be an effective biomarker in the diagnostic test MI.