Relation between the Recurrent Miscarriages in Women with Polycystic Ovary Syndrome and the Level of INHIBIN B Hormone

Abstract

Recurrent miscarriage, which is defined as the loss of two or more pregnancies in a row, affects 1% of couples trying to conceive. It has believed that 1–2% of first and second-trimester pregnancies end in miscarriage before the 24-week stage. PCOS (polycystic ovarian syndrome) is a prevalent endocrine condition that affects women of reproductive age. Women with PCOS are at risk for fertility issues (menstrual cycle disorders, failure to ovulate, late menopause, endometrial cancer, and infertility). Objective:- The purpose of this study were to evaluate the levels of INHIBIN B hormone in the serum of women who suffer from recurrent miscarriage with PCOS and to compare it with women of the control group, in addition to verifying its relation with obesity and maternal age. Subjects and method: - A case and control study includes 90 women in reproductive age (15-45), 50 of them had polycystic ovarian syndrome diagnosed, and 40 female were control group healthy. Samples were taken from October 2021 to March 2022, and INHIBIN B levels had analyzed by absorbance ELISA microplate reader and ELISA microplate washer from BioTek company in USA. INHIBIN B concentration was measured with a body mass index (BMI) calculated from weight divided by height in square metres (kg/m²). Result: - The levels of INHIBIN B in patients women that significantly decreased when compared with the control group (P=0.01). In addition, the level of INHIBIN B concentration in control group were the highest in Body Mass Index than patients with PCOS. Conclusion: - INHIBIN B level is decrease in PCOS patients. BMI proportion in patients was higher percentage in obese women. A high level of INHIBIN B was found in the first month of pregnancy. In addition, this hormone is associated with an increase in the number of recurrent miscarriages, where the hormone concentration on the date of the last miscarriage from one to four months is higher than the longest period of time.