Antibacterial Effect of Nano Silver on Bacteria Isolated from Human Skin Infections

Abstract

Background: Skin infections are one of the important infections in community with low response to antimicrobial agents due to resistant bacteria. Aims of the study: This study was devoted to throw light on role of nanosilver on the bacterial isolates and effect of such particles on bacterial antimicrobial resistance. Patients and methods: One hundred patients with different skin infections were included in this study, Skin swabs were taken from each patient and bacteriological investigations were done for each swab as soon as possible. Antimicrobial sensitivity diffusion test was done for the isolates pre and post treatment with nanosilver solution. Results: Seventy six (76) single and 10 mixed bacterial infections were isolated in this study. Stapylocoocus took the first rank of isolation (42, 55.26%) followed by pseudomonas aeruginosa (9, 11.8%) isolates while two (2, 2.6%) isolates of Burchkolderia cepacia were isolated. Other bacterial types were isolated within lower ratios. Majority of isolates were sensitive to ceftriaxone and resistant to other antibiotics. All bacterial isolates were sensitive to nanosilver (100%) except pseudomonas aeruginosa and Burchkolderia cepacia, they were showing (28.6 %) and (50%) for each respectively. Nanosilver particles showed positive results on gene expression in bacteria resistant to antibiotics leading to shift resistant bacteria to sensitive to antibiotics. Conclusion: In conclusion, different bacterial types are imposed in skin infections particularly Staphylococci. In spite of majority of bacterial isolates are resistant to antibiotics, ceftriaxion is still effective. Majority of bacterial isolates showed sensitivity to nanosilver particles.