Interactions between Some Inflammatory and Clotting Components in Patients Affected with Myocardial Infarction

Abstract

Myocardial infarction (MI), it means irreversible injury that cardiac muscle and can lead to sudden death. The present study was employed to explore whether the MI affects some inflammatory and clotting components, also the gender, body mass index (BMI) and age. A complete number of subjects involved in this research were 80 subjects of both patients and healthy individuals (men and women) and they classified into four categories according to their ages (40-49, 50-59, 60-69, and 70-79 years old). The results of this work had been explained that the incidence of MI proportionate with increase body mass index (25-33 kg/m was 70% of patients) compared to patients with BMI 19-23 kg/m was 30% out of patients. Data of inflammatory and clotting components including interleukin-6 (IL-6), D-dimer, and tissue plasminogen activator-1 (tPA-1) recorded a significant increase in men and women affected with MI in matching with those healthy individuals. Concerning the levels of studied parameters according to ages and gender groups, their levels were significantly higher (p<0.05) of old ages compared with those healthy counters of both sexes. In regard to BMI, the levels of IL-6, tPA-1, and D-dimer were significantly heightening (p<0.05) in patients who have high BMI (25-33 kg/m2) compared to those have BMI within 19-23 kg/ m2. The ROC analyses (AUC) of studied parameters (D-dimer=0.740, tPA=0.60, and IL-60.767) associated with cutoff 298.5, 5.175, 8.950, respectively. In conclusion, the changes in studied parameter may be return to systemic inflammation, increase BMI, and activation of fibrinolytic system of patients affected with MI.