Immunological Role of Cd24 in Women with Breast Cancer

Abstract

Breast cancer is the most common malignant tumor of females in the worldwide Breast cancer is the dangerous tumor that is formed from an abnormal cell. Its affect tissues involved in milk creation (Ductal and lobular tissues). The aim of study: To investigate whether CD24 can serve a prognostic indicator in breast cancer. This study conducted at the Middle Euphrates Center Cancer AL-Najaf Al-Ashraf Government during the period from the November 2021 until the March 2022. This study comprised 90 adult females with diagnostic breast cancer that including newly diagnosed of breast cancer before treatment chemotherapy (base line), female patients with chemotherapy treatment and female patients with hormone treatment for all types of breast cancer & 90 sample of control (female with negative breast cancer). The result showed there were highly significant increasing in the age group ≥ 45 (61.1%) while in the age <45 (38.9%) at (P= 0.035). According to BMI showed highly significant in the overweight (44.4%) whereas in the obesity (41.1%) and normal weight (14.4%) at (P= 0.001). According to the invasive ductal carcinoma high significant (76.7%), invasive ductal & lobular carcinoma (12.2%) and invasive lobular carcinoma (11.1%) at (P=0.0001) and with the grade of breast cancer, we showed the grade II high significant at (P= 0.0001). According to surgical type observed that mastectomy of surgical type was high significant (68.9%). CD24 property showed a significance between base line patient (105.92±11.07) & treated patients (11.08±1.85) as compared with healthy control (9.18±2.64) at (P=0.0001). the present study indication non-significant in the base line patients (before treated) at ((P= 0.776) of grade I II III and in treated patients(chemotherapy and hormone ) show non-significant at (P= 0.994), the white blood cells in base line non significantly at (P= 0.640) of grade I II III and in the treated patients we show non significantly at (P= 0.278), ESR that non-significant in the base line at (P= 634) and observed non-significant in the treated patients at (p= 0.204) and CD24 high significant in the grade III (116.97±4.93) of the base line at (P= 0.0001) and show high significance in the grade III (12.67±2.11) of the treated patients at (P= 0.0001). the Red Blood Cells observed non significantly between the surgical types at (P= 0.197), White Blood Cells indicate that high significantly in the biopsy was compared with the other lumpectomy and mastectomy at (P= 0.025), Erythrocyte sedimentation rate observed highly significant in the biopsy were matched with other surgical types at (P= 0.021). CD24 show that observed high significant in the biopsy were compared with other surgical types at (P= 0.0001). The conclusion indicated that CD24 considering a baseline prognostic indicator for breast cancer patients, the most common type of breast cancer was invasive ductal carcinoma and mastectomy was the most beneficial surgically.