Estimation of Polycyclic Aromatic Hydrocarbons (Pyrene and Benzo[a] Pyrene) and Association with levels of benzo[a]pyrene-7, 8-diol-9, 10-epoxide-DNA adduct in a Sample of Iraqi Workers at Hilla City

Abstract

Some of PAHs are known to be human carcinogens and we have therofre developed a methodologe of measuring their circulating concentration as a tool for assessing endogenouse dose and health risks. The results of current study indicated that there is a highly significant difference in PAHs levels (pyrene and B[a]P) (p= 0.0001) between the car repairers and spare part sellers groups and no PAHs detected in controls group. Also there is a highly significant increase of BPDE-DNA adduct level (p= 0.0001) in the repairers group compared to the groups of spare part sellers and control together. There is significant (p= 0.027) positive correlation between B[a]P and BPDE-DNA adduct, while no significant, and a positive correlation between pyrene and BPDE-DNA adduct. As results of prolonged exposure to the higher levels of PAHs that Iraqi car repaiers suffer from, they have highe levels of these toxic agents in their blood, which increases their carcinogenic effect of these carcinogens that begine with PAH-DNA adduct.