The Relationship between Insulin Resistance and Hypertension in Patient with Hypertensive

Abstract

Two things commonly occur with patients including untreated hypertention: Insulin resistance and the compensatory hyperinsulinaemia. Coexistence of these two can view like cause-effect relationship or can view like a noncausual association. Blood pressure can be increased through different mechanisms. It can occur for increase of renal sodium reabsorption, or for sympathetic-nervous systems activation, or can occur for transmembrane-ion transportations alteration or even for the resistance vessels hyperthrophy. Insulin and glucose delivery to the skeletal muscle cells can alter the insulin resistance and it cause hypertension. Impaired glucose uptake results by this. Vasodilation of skeletal muscle can impair by hypertension and the vascular structural changes and rarefactions to vasoconstrictor stimuli with increased response. Insulin resistance development may be contributed by 2b fibre type muscles prevalence. Moreover, these two (insulin resistance, hypertension) contains a similar pathogenetic mechanism. Sympathetic nervous systems activation is that mechanism. It shows the result in vasoconstriction. This can also contribute to vascular structural changes genesis and as a result, the fast twitch fibres may increase. At last, these objectives (hypertention, insulin resistance) can find as noncausual association like the hypotheses provided below:

1. Can found two consequences of similar metabolic disorder (independent)or,

2. Resistance of insulin is genetic marker as well as it is a pathogenetic mechanism. In this mechanism, hypertension gets frequently associated with multiple metabolic abnormalities