Association of Hepcidin Gene Polymorphism and Iron Levels in Obese Patients with Covid-19
Abstract
Covid-19 is a genus of enveloped, positive-sense, single-stranded RNA viruses with a high degree of genetic diversity. They induce a variety of disorders affecting the respiratory, gastrointestinal, hepatic, and nervous systems in humans and animals, with different manifestation and severity.
Obesity is the result of the accumulation of an excessive amount of fat in the body and the condition arises from an imbalance between the amount of energy stored by increased food intake and the amount of energy expended as physical activity.
The aims of study are evaluate the effect of covid-19 on iron levels in obese patients and study there correlations. As well as, study the association of hepcidin gene polymorphism to the risk of infection with covid-19 in obese patients.
This study is cross sectional. Which include conducted in isolation wards at Al-Amal Hospital and Al-Hakim hospital in Al-Najaf City for the period extending from November 2021 to the end of March 2022, 60 sample were collected from diagnosed patients with covd-19 and obese (BMI more than 30) . On the other hand 60 sample of individuals that suffering from obesity (BMI more than 30) and recovered from covid-19 for more than six months.
The variables was measured in this research are: ferritin, serum iron, unsaturated iron binding capacity (UIBC) and total iron binding capacity (TIBC). Also gene polymorphism of hepcidin hormone G71D (HAMP).The results showed that there were significant differences for (ferritin, serum iron, UIBC and TIBC), in obese patients with covid-19 compared to recovery from covid-19. The gene polymorphism of hepcidin show no significant difference between obese patients with covid-19 and obese recovery from covid-19.
the conclusion obese people are the most risk factor to covid-19 infection due to association of obesity with change in BMI and increase Adipose tissue mass in obese individuals, As well as Ferritin test is the most accurate biomarker to covid-19 infection while Gene polymorphism study of SNPs hepcidin G71D (HAMP) gene represent a weak maker for covid-19 disease.
