Resveratrol Improve the Adipokines levels in Induced Diabetes Mellitus Model
Abstract
Background: The insulin-sensitizing ability of resveratrol has been studied mostly in experimental animals, with results showing a substantial improvement in insulin sensitivity and/or a reduction in circulating insulin concentration.. The adipose tissue produces a class of bioactive chemicals known as adipokines, which function as both paracrine and endocrine hormones. There was a direct regulatory effect for insulin on adipokines release.
Aim of study: The current study aimed to evaluate the effect of resveratrol on adipokines levels in relation to diabetes mellitus.
Methods: Thirty six male rats were divided into 6 groups I: Negative control group, group II: Positive control diabetic induced by alloxan (120mg/kg), group III: diabetic rats treated with metformin 120 mg\kg\day after DM induction by alloxan (120mg/kg),, group IV: diabetic rats treated with resveratrol 5 mg/kg, Group V: diabetic rats treated with resveratrol 10 mg/kg,group VI: diabetic rats treated with resveratrol 20 mg/kg . Lipocaline2, Angiopoten like protein 2 LCN2, blood glucose, insulin, HBa1c were measured. HOMA and weight were also recorded.
Results: This study showed an elevation in the lipocaline 2 level between negative and positive control groups. In diabetic group, lipocalin levels were increased from (8.63 ± 1.48 - 14.55 ± 1.1 ng/ml), significant 37% reduction (14.55 ± 1.1 to 9.2 ± 0.78 ng/ml) was found after treatment with 20 mg resveratrol compared with the positive control group at (p ≤ 0.01), also showed significant raise between negative and positive groups, diabetes rises angiopoietin levels (from 370.63 ± 24.4 to 572 ± 72.4 ng/l), (p <0.001), significant difference were found only between the use of 20 mg resveratrol and positive control groups (p =0.02) i.e. the use of 20 mg of resveratrol lowers angiopoietin levels (from 572 ± 72.4 to 412.5 ± 81 ng/l). No difference was found between use of 20 mg resveratrol and negative control group (p> 0.05).
Conclusions: Resveratrol improve the levels of lipocaline2, Angiopoten like protein 2 and glycemic status.
