Study of Histopathological Changes of Silver Nanoparticles in Liver of Coturnix Bird

Abstract

Silver nanoparticles (AgNPs) are one of the most widely used particles in the nanotechnology industry because of their antibacterial, antifungal and antiviral properties that enter the blood stream and then organs through inhalation, skin and mouth. This study was conducted to investigate the histological changes caused by silver nanoparticles on the liver of Japanese quail. At this search 100 birds were obtained from the College of Agriculture and Forestry and were distributed into five groups, each of which included 20 birds. The first and second group were dosed orally for 30 days with AgNPs, and the third and fourth groups were dosed for only 3 days, in addition to the fifth group, which is the control group, which was dosed for 30 days with distilled water. Results appeared after 10 days of treatment, changes in the tissue structure of the liver, represented by the expansion of the sinusoids, the severity of Hemorrhage, the emergence of inflammatory focal, thickening and congestion of the blood vessel. The results showed more severe after 30 days of treatment, as the inflammatory focal increased, fatty change of Hepatic cell and an increase in the thickness of the hepatic portal artery and bile ducts. Silver NPs showed histological changes, which were more severs at high concentrations, as it showed vascular congestion, hepatocyte damage, severe Hemorrhage, hepatic portal artery thickness and a Hyperplasia of bile canaliculi. The nanosilver has toxic effects on the liver of quail Japanese.