Antifungal Investigations of Synthesized new Transitional Bivalent Metal Complexes Derived from 4-Methyl phenol

Abstract

In this work new series complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Au(III) were prepared and characterized using a new azo ligand (HMDP) from coupling reaction of 4- Aminoacetophenone with 4-methyl phenol. The structures of the free ligand and the complexes were characterized using several techniques, including molar conductance, elemental analysis (C.H.N), electronic spectral, magnetic measurements, 1HNMR, FT-IR, and mass. The data values indicated octahedral geometry with a genral formula [ML2(H2O)2] for Co(II), Cu(II), Ni(II), Zn(II) and Cd(II) metal ions, and square planar geometry [ML(H2O) Cl] Cl for Au(III) central ion, in which ligand behaves as abidentate donor. The metal ion complexes showed higher significant antimicrobial activity against C. albicans fungi comparing to their corresponding ligand.