Synthesis of new Semi Nucleoside from Indole and Investigation Biological activity and its effect on DNA.

Abstract

This study focused on the widely used indole derivatives in medical fields, which were prepared by substitution reaction on the C3 position, then protecting the position 1 by a good leaving group until it is replaced with a pentacyclic sugar such as the compound KI3, KI5, KI10, and identification of these aforementioned compounds by HNMR and IR spectra. The inhibition zone was studied against positive and negative bacteria, fungi and the effect of their binding with DNA.