Correlation of Fibroblast Growth Factor 23 and Parathyroid Hormone in Chronic Kidney Disease patients

Abstract

Chronic kidney disease (CKD) is a growing international health concern with high mortality rate in the world today characterized by alterations in either kidney structure or function or both for a minimum of 3 months duration. Levels of PTH (Parathyroid hormone)and the FGF23(Fibroblast growth factor 23), increase early in CKD . This study was designed to show the Correlation of FGF23 and PTH in chronic kidney disease patients. One hundred blood samples have been collected from Al-Yarmouk Teaching Hospital, Baghdad Teaching Hospital and Al-Karama Teaching Hospital during the period from December 2021 to March 2022 besides 50 samples as apparently healthy control. The age groups in the current study was at 33-75 years for CKD patient and 30-65 years for control. Then the blood samples were taken from patients and healthy volunteer groups to screen fibroblast growth factor 23 by ELISA method and PTH by cobas e411 analyzer. The current study shows that the increase level of FGF23 was correlated with PTH. PTH, FGF23 is statistically highly significant at p-value =0.001. The receiver operation characteristic (ROC) curve results revealed the sensitivity and specificity for FGF23 was 100%.The conclusion of the current study appear that the FGF23 in CKD patients was higher when correlated with PTH.