Evaluation of Irisin Level in Hypothyroidism with Hyperlipidemia Patients
Abstract
The study was conducted at the Specialized Center for Endocrinology and Diabetes in Al-Sadder Medical City in Najaf Governorate, Iraq throughout the period from first of April to first of September 2021 to determine the relation between physiological, immunological and biochemical marker in hypothyroidism with hyperlipidemia in both sexes. The study was included 90 blood samples, 60 blood sample from male and female affected with hypothyroidism with hyperlipidemia where their age ranged between 20 to 60 years and 30 blood samples as a control group in the same age range. Body mass was measured for both groups.
Blood samples of male and female with hypothyroidism and hyperlipidemia and control were divided into Three groups depending on patients age, the first age group (20-34) years (27 samples), the second group (35-49) years (13 samples), the third group (>=50) years (20 samples), and were divided into Three categories depending on BMI the normal weight in patients (7 sample) and control (13 sample), overweight patients (22 sample) control (11 sample) and obesity patients (31 sample) control (6 sample) respectively.
The study compared the age, gender, BMI, and lipid profile, thyroid hormone and Irisin biomarker in patients with hypothyroidism and hyperlipidemia to control group. The results revealed that there were no significant differences in age (P>0.05) between patients and controls, while there were significant differences (P<0.05) in gender, BMI and lipid profile, thyroid hormone and Irisin biomarker between patients and controls.
The study compared the level of Irisin biomarker between male and female patients, the result showed significant differences in Irisin level (P<0.05) between male and female patients.
The study showed that the effects of age categories on Irisin level in patients, the results showed that Irisin level was significant (P<0.05) between age categories in patients.
As well as, the study showed that effects of BMI categories on Irisin level in patients the results showed that the Irisin level was significant (P<0.05) between BMI categories in patients.
The study showed that there was significant correlation between Irisin levels and age, lipid profile and thyroid hormone in patients, the results showed that negative correlation of Irisin levels with age, Total Ch, TG, LDL, VLDL and TSH, But positive correlation with HDL, T3 and T4.
In conclusions Irisin levels are decreased in patients with hypothyroidism with hyperlipidemia. Our results suggest that decreased irisin levels are directly associated with reduced thyroid hormone levels.
