Study the oxidized LDL as a useful marker for identifying patients with coronary artery disease and myocardial infarction

Abstract

Background: Coronary Artery Disease (CAD) is one of the most common cardiovascular disorders, and the leading cause of fatalities worldwide, in both developed and developing countries. Biomarkers such as oxidized LDL (oxi-LDL) can be used to identify patients with CAD and MI and play a key role in improving cardiovascular risk prediction. Aims: assess the diagnostic value of oxidized LDL as a possible predictive biomarker for CVD patients. Results: The mean Ox-LDL levels in the MI patients, with or without DM, were statistically significantly higher than its level in the controls, also it was observed that the biomarker was statistically significantly changed in patients comparing to control group. Area under the ROC curve (AUC) of 0.905, suggesting its high diagnostic accuracy in MI. The cut-off value of oxi-LDL for MI diagnosis was 67.68, with sensitivity of 79.4% and specificity of 96.3%.

Conclusion: Circulating oxi-LDL is a promising sensitive biomarker of CAD in MI patients and MI suffering from DM.