Exploring Role of Some Physiologic Biomarkers and Serum Parameters in Early Detection and Progression of Asthma in the Iraqi Population.

Abstract

Asthma is a common chronic lung disease in which the airways (bronchi) become inflamed and are abnormally sensitive to certain triggers. Asthma can affect people of all races and ages, and although there is no known cure, there are many ways to control it. The symptoms of asthma include coughing, shortness of breath, wheezing, and chest tightness. This study was carried out in Al-Sadr Teaching Hospital/ Allergy and Asthma Center and Al-Hakim Hospital/ Chest and Respiratory Diseases Center in Al-Najaf province -Iraq and laboratory of molecular biology in the Department of Biology / Faculty of Science – University of Kufa. The study population was included 70 Asthma and 20 healthy subjects. The estimated incidence of Asthma in the age group 33-51 years with a percentage of 55.71% recorded a significant increase (P<0.05) compared to the rest of the age groups, followed by the age group 15-32 years with a percentage of 24.29% and 52- 70 years with a percentage of 20%. The levels of erythrocyte sedimentation rate (ESR) in patients and the healthy group, where the results of the study showed a significant increase (P<0.05) ESR of the patients (22.77±1.98 mm/hr) compared with the healthy group (14.20±2.86 mm/hr). The cortisol variable recorded a significant decrease (P<0.05) in the patients (6.51±0.62 g/dL) compared with the healthy group (11.82±0.81 g/dL). The results recorded a significant increase (P<0.05) for non-smokers by 84.29% compared with smokers who scored 15.71%. The reason for the prevalence of asthma among smokers is that smoke irritates the airways, thus making them swollen, narrow, and filled with sticky mucus - the same things that happen during an asthma attack, this is why smoking can cause asthma flare-ups (or so-called "attacks"). Oftentimes, they may also be more severe and difficult to control, even with treatment with medication. And the results of the current study indicated that there is a relationship between frequency of blood group (A) and (B) with asthma in patients compared with the group of controls