Antihyperlipidemic Potential of Siddha Formulation- Pavala Veera Chunnam in High Fat Diet Induced Hyperlipidemic Rats

Abstract

Background: Hyperlipidemia is a known risk factor for cardiovascular disease (CVD). Statin group of drugs suppress a rate-limiting stage in cholesterol production, yet all statin medications have musculoskeletal adverse effects. As a result of the present interest, traditional siddha sources are being searched for new lipid-lowering medicines with minimal or no side effects. Objective: The main objective of the present investigation is to evaluate the antihyperlipidemic potential of the siddha formulation Pavala Veera Chunnam (PVC) in high fat diet (HFD) fed rats. Methods: HFD mediated obese model was adopted for the induction of hyperlipidemia in the experimental animals. The animals were divided into control, disease control and treatment groups. Rats belongs to treatment groups were administered test drug PVC at doses of 200 and 400 mg/kg/p.o. Results: The data of the present investigation clearly emphasise that the body weight, total cholesterol, HDL, LDL, VLDL, and triglyceride levels of the HFD group demonstrate a significant increase in comparison with normal control rats. Treatment with the siddha formulation PVC at 200 and 400 mg/kg doses results in a significant decrease in the total lipid profile and body weight of the experimental animals. Furthermore, the PVC treatment causes a consistent decrease in the internal organ weight (heart and liver) of the animals. Histological examination of the liver sample confirms the existence of inflammatory changes in HFD treatment, and treatment with PVC reveals a restorative nature in both the dose level. Conclusion: In conclusion, the data of the present study show that the siddha formulation PVC reveals promising antihyperlipidemic activity in HFD-fed rats. Hence PVC type formulations may be considered an alternative drug of choice in the clinical management of hyperlipidemia.