Evaluation of genotoxic and cytotoxic doliprane on cultured lymphocytes

Abstract

The main objective was to evaluate the genotoxicity and compare it with the use of the simplest painkiller prescribed to the patient and what are its effects on lymphocyte culture with different concentrations (0.05, 0.1, 0.5, 1, 1.5, 2, 2.5, and 3mg/ml), and the result was the discovery of cell damage, deformation of divisions, and thus chromosomal changes and the emergence of micronuclei in Cell divisions at high concentrations, where the highest concentration in which divisions appeared was 2.5 mg/ml. Knowing which regions of the chromosome are associated with the effect of this drug is an important first step.