CBC and Total Antioxidant Capacity in Breast Cancer Patients After Radiotherapy

Abstract

Background: The term "cancer" refers to disorders in which aberrant cells proliferate unchecked and can infect other tissues. The lymphatic and vascular systems of the body can allow cancer cells to spread to other areas of the body. The most frequent method of irradiation used in radiotherapy to treat cancer patients is the use of an external beam of photons or electrons. X-ray or Y-ray photons are thought of as energy bundles that deposit dosage as they go through material. Objectives: 1-How radiation therapy affects the blood system and some blood parameters 2- The effect of radiotherapy on antioxidant capacity in serum level Methods: 90 women participated in this study, and they were split into three primary groups: Group I: 30 individuals with stage II-stage III invasive breast cancer; Group II: The same 30 patients After Radiotherapy, Group III: 30 healthy women as a control group. After surgery and chemotherapy, all patients in the study got adjuvant radiation. For physiological study Hematological analyzer device is used for complete blood count (CBC) to measure White Blood Cells (WBC) and its differential Granulocyte (GRA), Monocyte (MON), Lymphocyte (LYM) and Red Blood Cells (RBC), Platelet (PLT) , Hematocrit (HCT), Hemoglobin (HGB). For biochemical study the enzyme-linked immunosorbent test was used to quantify Total Antioxidant Capacity (T-AOC). Results: There was a significant decrease occurred in the percent (WBC) between Group I patients and Group III control, while its differential shows (LYM) significantly increases and (GRA) significantly decreases. Also (HGB) significantly increase and no change to other parameters. A significant decrease occurred in the percent of (WBC) between Group I patients and Group II patients After Radiotherapy and it's differential shows significant decrease in (LYM) and significant increase in (GRA) while no significant changes in other parameters.(T-AOC) shows significant increase between Group I and Group II After radiotherapy while no change between Group I and Group III. Conclusion: There was an effect of radiotherapy on (WBC) and its differential and on (T-AOC).